Following the completion of the course the students will be able to describe the basic principles of 3D genome organisation and how this relates to nuclear functions such as transcription, replication, DNA repair and telomere maintenance. The students will also be able to design experiments for studying the 3D structure of chromatin, compartmentalisation of nuclear functions in the nuclear space and to critically evaluate results obtained with these techniques.
The course covers the basic principles of genome regulation in 3D and how marks of the primary chromatin fibre relate to the 3D structure of chromatin. Particular attention will be paid to the regulation the nuclear architecture during development, and its role in lineage specification by means of coordination of transcription and replication in space and time. Speakers will include the course organizers and several well-known international researchers dedicated to research on relevant aspects of chromatin.