The epigenome: a platform for the integration of metabolic and signaling pathways in development and on the path to diseases

Learning outcomes

Following the completion of the course the students will be able to describe and discuss the basic principles of epigenetic regulation and the role of chromatin in the maintenance of cellular phenotypes. Moreover, the students will learn how various signaling and metabolic pathways alter chromatin states during ageing and in human diseases, such as cancer, diabetes and psychiatric disorders. The students will also be able to design experiments for studying chromatin marks and to critically evaluate results obtained with these techniques.

Content of the course

The course covers the molecular mechanisms of epigenetic regulation and how chromatin based processes are linked to human diseases. Particular attention will be paid to the crosstalk between chromatin marks and cellular signaling pathways as well as metabolism. Furthermore, we will discuss the regulation of these processes during the circadian cycle and their deregulation in cancer, diabetes mellitus and psychiatric diseases. Speakers of the course will include the course organizer and several well-known international scientists studying various aspects of chromatin.

Teaching and learning activities

The learning activities used in the course include lectures, research seminars, group discussions, problem-based learning and research article presentations by the students. Every student will present a recent publication in the form of a journal club. Students will also be encouraged to actively participate in the course. There will be substantial time for discussions after the lectures and research seminars.